Clinical Study Coordination Services

Studies Currently Enrolling in the ED

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All of Us

The All of Us Research Program aims to build a national database that will be available to researchers to further precision medicine. Coordinators will approach patients to participate, help them go through the portal to complete the baseline surveys, and schedule follow-up appointments with patients for bio-specimen collection. We are hoping to enroll family members and guests in this study as well. For questions, please contact Dr. Manish Shah at mnshah@medicine.wisc.edu.

All of Us research program: the future of health begins with you

Building a Substance Use Data Commons for Public Health Informatics

This study aims to validate a natural language processing algorithm that screens hospitalized patients for substance misuse. The EDRCs will be approaching eligible patients and informing them of the study – no study activities will occur in the emergency department. The EDRC team is working with Majid Afshar, MD, MSCR from the UW Division of Allergy, Pulmonary and Critical Care Medicine and Randy Brown, MD, PhD from the UW Program for Research, Outreach, Therapeutics, and Education in the Addictions (PROTEA) to see how their teams’ substance misuse classifier performs against a gold standard screening survey.

Please contact Dr. Manish Shah at mnshah@medicine.wisc.edu or Dr. Brian Patterson at bpatter@medicine.wisc.edu with questions.

COVID-19 Vaccination Among Emergency Department Patients or the Adult Companions of Pediatric Patients

The emergency department (ED) is a unique setting that frequently acts as a healthcare safety net and may be the site of a disproportionate number of unvaccinated individuals. This research project aims to determine if adult companions of pediatric ED patients are getting vaccinated at the same rate as the general population and if there are underlying variables that can be addressed to encourage vaccination. The ED Research Coordinators will be administering a brief survey to adults accompanying pediatric ED patients to evaluate both the adult and child’s vaccination status and potential barriers to getting vaccinated. The ED Research Coordinator team is working with Dr. Brooke Lerner from the Department of Emergency Medicine at the University of Buffalo.

For questions about this study, please contact the principal investigator at UW-Madison, Dr. Kendra Fabian, at klfabian@medicine.wisc.edu.

Evaluating the Utility of Thermal Imaging in Diagnosing Cellulitis for Lower Extremity Complaints in the Emergency Department

The main purpose of the study is to determine the temperature gradient between affected and unaffected legs in patients with cellulitis and compare the difference in temperature between cases of cellulitis and pseudocellulitis. A secondary purpose is to assess the impact of thermal imaging data on diagnostic assessments of potential cellulitis cases when added to standard techniques.

For questions, please contact Dr. Michael Pulia at mspulia@medicine.wisc.edu.

Improving Patient Classification and Outcome Measurement in Traumatic Brain Injury

Many clinical trials on traumatic brain injury (TBI) have failed in the past due to knowledge gaps on the heterogeneity of patient profiles and limitations in clinical outcome measurements. The aim of this study is to better understand TBI sub-types and to identify more precise outcome measures to facilitate how research is conducted on TBI.

The ED research coordinators will be completing multiple visits with patients for this longitudinal study. The acute visit occurs at the initial ED counter and includes data collection regarding past medical history and the mechanism of injury. Subsequent visits include standardized cognitive assessments and formal and informal questionnaires to understand functioning prior to injury. Coordinators will also obtain specimens from each patient for analyses aimed at identifying biomarkers present during each phase of recovery.

This study is being conducted in collaboration with Lyndsay Nelson, PhD, ABPP, from the Brain Injury Research Program at the Medical College of Wisconsin. If you have questions about this study, please contact the study PI, Dr. Marin Darsie, at medarsie@medicine.wisc.edu.

Investigating Emergency Department Clinician Views on Naloxone Dispensing and Initiation of Medications for Opioid Use Disorder

The drugs naloxone (Narcan®) and buprenorphine are powerful tools in the treatment of opioid use disorder but may be underused, especially in emergency care settings. This study aims to investigate emergency department providers’ knowledge and attitudes in order to inform education efforts, and ultimately provide better care to people living with an opioid use disorder. To this end, ED Research Coordinators will distribute anonymous surveys to all nurses and social workers in the emergency department. Physicians and physician assistants will complete the surveys electronically.

This study is a collaboration with Dr. Collin Michels (Department of Emergency Medicine) and Dr. Salisbury-Afshar (Department of Family Medicine and Community Health). For questions about this study, please contact Dr. Michels at ctmichels@medicine.wisc.edu.

The Role of Aspiration in Community Acquired Pneumonia

Pneumonia is the most common infectious cause of mortality in older adults. Standard practice for older adults with pneumonia involves hospitalization and antibiotics. However, recent studies suggest that a significant portion of suspected community-acquired bacterial pneumonia cases may actually be due to distinct, dysphagia-related aspiration syndromes (e.g. aspiration pneumonia, pneumonitis). This study will utilize diagnostic imaging to generate a prevalence estimate for aspiration in older adults diagnosed with pneumonia or with suspected pneumonia for dysphagia, as well as determine rates of recurrent pneumonia in this population.

This study is being conducted in collaboration with Nicole Rogus-Pulia, PhD, CCC-SLP, Director of the Swallowing and Salivary Bioscience Laboratory within the UW Department of Medicine Division of Geriatrics. This study is funded by the UW Office of the Vice Chancellor for Research and Graduate Education.

For questions, please contact Dr. Michael Pulia at mspulia@medicine.wisc.edu.

Romantic Couples, Medications, and Health at Time of Emergency Department Visit

The purpose of this study is to develop relationship-based predictors of prescription opioid use among older adults. EDRCs will approach patients presenting to the ED with injuries who also have a romantic partner present for participation. Interested couples will complete one survey in the ED, and the patient will complete a short follow-up survey at 30 days. This study is being done in collaboration with Dr. Lauren Papp in the School of Human Ecology. For questions, please contact Dr. Michael Repplinger at mdreppli@medicine.wisc.edu.